PT-141 (Bremelanotide) 10 MG – Melanocortin Peptide for neuroendocrine signaling & Neuroendocrine Research

Product Description

PT-141 (Bremelanotide) – Melanocortin Receptor Agonist for melanocortin pathway activation and Neurohormonal Studies

Composition: 10 mg PT-141 (lyophilized peptide powder)
Category: Peptide
Form: Vial with freeze-dried powder
Administration: Subcutaneous research application (requires reconstitution)

What is PT-141?

PT-141 (Bremelanotide) is a synthetic analog of alpha-melanocyte-interacting with hormone (α-MSH), belonging to the melanocortin family of peptides.
Unlike PDE5 inhibitors that act on the vascular system, PT-141 targets the central nervous system by binding to melanocortin receptors (MC3R and MC4R) to modulate melanocortin pathway activation and neuroendocrine activity.

It has been investigated in both male and female models for its effects on sexual motivation, neural activation, and hormonal signaling.
Preclinical data also suggest roles in mood regulation, reward mechanisms, and sympathetic neural activity.

➡️ Ideal for research on melanocortin pathway activation, melanocortin signaling, and neuroendocrine modulation.

Key Research Findings

• Central Receptor Activation: interacts with MC3R and MC4R receptors in the hypothalamus, influencing neural signaling and motivational pathways.
• Non-Vascular Mechanism: Acts on central neural circuits rather than peripheral blood vessels – a unique distinction from PDE5 mechanisms.
• neuroendocrine signaling Optimization: Shown in preclinical and clinical models to studied for potential influence on neural signaling responses in both sexes.
• Behavioral and Neurochemical Effects: Linked to dopaminergic and sympathetic pathways that govern motivation and reward.
• Short Onset & Controlled Duration: Provides rapid neural activation with manageable half-life for timed research designs.

Mechanism of Action

PT-141 binds to melanocortin receptors in the hypothalamic region of the brain, especially MC4R, which plays a pivotal role in neuroendocrine signaling and energy balance.
This interaction initiates a cascade of neuropeptide and neurotransmitter release, supporting sympathetic activation and behavioral neural signaling independent of nitric-oxide-mediated vasodilation.

Dosage and Application

Reconstitute with bacteriostatic water before use.

Commonly referenced research protocols: 0.5 – 2 mg per application used in subcutaneous research models, depending on study design and timing requirements.
Often applied 30–60 minutes prior to the intended research phase in behavioral or neuroendocrine studies.

Store the reconstituted solution in a refrigerator and use within 30 days.

Storage Instructions

• Store at 2–8 °C (36–46 °F)
• Protect from light and moisture
• Do not freeze
• Avoid temperature fluctuations

Why Choose PT-141?

PT-141 represents a new class of melanocortin-based peptides that act centrally on the brain to influence sexual motivation and neuroendocrine signaling.
Its distinct mechanism, rapid onset, and broad research relevance make it a valuable compound in studies of neuroendocrine pathways, mood, and autonomic response pathways.

Explore the potential of PT-141 (Bremelanotide) 10 mg for advanced research in neuroendocrine signaling, neuroendocrine regulation, and behavioral science.

Technical Specifications

• Product Code: PT141-10MG
• Purity: ≥ 98% (HPLC)
• Form: Lyophilized powder
• Storage: –20 °C (before reconstitution), 2–8 °C (after reconstitution)
• Stability: 2 years lyophilized, 30 days reconstituted when properly stored

Quality Assurance

Every batch undergoes rigorous quality control including:

• HPLC analysis for purity verification
• Mass spectrometry for molecular identity confirmation
• Endotoxin and sterility testing for research-grade consistency

References and Further Reading

For detailed information, consult peer-reviewed literature available on PubMed regarding PT-141’s role in melanocortin receptor activation, neuroendocrine signaling, and neuroendocrine pathways.
All products are produced in accordance with current research standards and laboratory best practices.